This step by step tutorial will help you to disable the USB Storage Devices in your PC .This can be done by Third party software or by simple tweak in Registry Editor .
Now I am going to do using Registry Editor .
Step 1 :Open Registry Editor
Step 2 : Navigate through following Path
RegeditHKEY_LOCAL_MACHINE > SYSTEM > CurrentControlSet > Services > USBSTOR
Step 3: Double Click the Start option
By Default , Value is 3 . It means USB Storage Devices are enabled .
To disable USB Devices , change the value data to 4 .
That’s it , USB Storage devices are Disabled .